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M9550223.TXT
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1995-03-04
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Document 0223
DOCN M9550223
TI Mother-to-child HIV-1 transmission: quantitative assessment of viral
burden as a diagnostic tool and prognostic parameter in HIV-1-infected
children.
DT 9505
AU De Rossi A; Ometto L; Zanotto C; Salvatori F; Masiero S; Mammano F;
Chieco-Bianchi L; Institute of Oncology, University of Padua, Italy.
SO Acta Paediatr Suppl. 1994 Aug;400:25-8. Unique Identifier : AIDSLINE
MED/95135013
AB Polymerase chain reaction was performed in 251 infants born to
HIV-1-seropositive mothers to diagnose HIV-1 infection. Assay
specificity was invariably > 95%, regardless of age at testing, while
sensitivity ranged from 15% in neonates (within 48 h of birth) to > 95%
in infants over 1 month of age. Evaluation of viral burden in 43
infected infants by means of quantitative DNA-PCR disclosed that the
number of HIV-1 proviruses ranged from 5 to 947 per 100,000 peripheral
blood mononuclear cells. Clinical follow-up demonstrated that a high
viral burden was associated significantly with disease onset.
DE *Disease Transmission, Vertical DNA, Viral/*ANALYSIS Female Human
HIV Antibodies/BLOOD HIV Antigens/BLOOD HIV Core Protein p24/BLOOD
HIV Envelope Protein gp120/BLOOD HIV
Infections/*DIAGNOSIS/IMMUNOLOGY/TRANSMISSION/VIROLOGY *HIV-1 Infant
Infant, Newborn Leukocytes, Mononuclear/VIROLOGY *Mothers *Polymerase
Chain Reaction Prognosis Sensitivity and Specificity Support,
Non-U.S. Gov't JOURNAL ARTICLE
SOURCE: National Library of Medicine. NOTICE: This material may be
protected by Copyright Law (Title 17, U.S.Code).